Biologically Active Atrial Peptides (American Society of Hypertension Series Vol 1)

Uncover the groundbreaking research on atrial peptides with "Biologically Active Atrial Peptides (American Society of Hypertension Series Vol 1)," edited by the renowned Barry M. Brenner. This comprehensive hardcover volume, published in 1987 by Raven Pr, delves into the intricate world of atrial natriuretic peptide (ANP) and its profound impact on cardiovascular and renal function. At 626 pages, this book, while a product of its time, remains a foundational text for understanding the complex mechanisms governing fluid and electrolyte balance in the body. Explore the cutting-edge findings of the era, detailing the amino acid sequence of circulating atrial peptides, including their prohormone and preprohormone forms, gene structure, and the characteristics of their target tissue receptors. Gain valuable insights into post-receptor events, particularly the pivotal role of cyclic GMP as a second messenger in mediating the diverse actions of atrial peptides. This in-depth exploration examines ANP's influence on vasorelaxation, natriuresis, diuresis, and the inhibition of adrenal aldosterone biosynthesis, painting a comprehensive picture of its multifaceted physiological effects. The book offers a thorough analysis of the cardiovascular and renal actions of ANP, including its interactions with key organs and tissues like the kidney, blood vessels, and adrenal cortex. Readers will find detailed discussions on the role of ANP in both short-term and long-term maintenance of water and electrolyte balance, crucial for overall homeostasis. While subsequent research has built upon these initial findings, this volume provides essential historical context and a deep dive into the early understanding of ANP's physiology, pharmacology, and pathophysiology. It's a valuable resource for researchers, students, and clinicians seeking a solid foundation in the biological actions of atrial peptides. Authored by a giant in the field, this book continues to be a critical resource for understanding the fundamentals of hypertension and cardiovascular health. This book is a must-have for medical libraries, researchers, and anyone passionate about delving into the underpinnings of hypertension. Discover the origins of our understanding of ANP, a key player in regulating blood pressure and fluid balance.