Protein Surface Recognition: Approaches for Drug Discovery

Discover the cutting-edge frontier of drug discovery with "Protein Surface Recognition: Approaches for Drug Discovery," a groundbreaking exploration into targeting protein-protein interactions to combat human disease. This comprehensive hardcover, published by Wiley in 2010, delves into the innovative strategy of designing molecular therapeutics that complement functionality along extended protein surface patches, offering a novel approach to inhibiting crucial protein-protein interactions. Traditional drug discovery often focuses on targeting active sites within proteins. This book introduces a paradigm shift, highlighting the potential of disrupting protein-protein interactions (PPIs). PPIs are fundamental to virtually every cellular process, and their dysregulation is implicated in a wide range of diseases, including cancer, neurodegenerative disorders, and infectious diseases. By targeting the protein surface involved in these interactions, researchers gain the opportunity to selectively modulate these complex biological pathways. "Protein Surface Recognition" offers a detailed roadmap for medicinal and bioorganic chemists seeking to navigate this burgeoning field. It begins with an extensive overview of protein-protein interactions crucial to human health, emphasizing their therapeutic potential. The book then dissects the fundamental physical principles that govern these interactions, providing a solid foundation for designing ligands that effectively bind to protein surfaces. The authors illuminate this with real-world examples of successful protein surface-small molecule interactions, including insights into protein-natural product interactions, protein-interface peptides, and rational design methodologies. What sets this book apart is its focus on practical application. It not only explains the theoretical underpinnings but also provides a comprehensive survey of the cutting-edge techniques essential for discovering new small molecule protein surface binders. Readers will gain insights into high-throughput synthesis and screening methodologies, as well as in silico and in vitro methods for identifying novel protein ligands. This "intellectual toolkit" empowers researchers to translate theory into tangible results, accelerating the drug discovery process. This first edition, authored by leading experts in the field, is invaluable for researchers in medicinal chemistry, bioorganic chemistry, chemical biology, and pharmacology. It is also a valuable resource for graduate students and advanced undergraduates seeking a deeper understanding of modern drug discovery strategies. Whether you are a seasoned researcher or an aspiring scientist, "Protein Surface Recognition: Approaches for Drug Discovery" provides the knowledge and tools necessary to unlock the potential of protein surface targeting for therapeutic intervention. Dive into this transformative field and contribute to the next generation of life-saving medications. Explore the future of pharmaceuticals today!